CROSS REFERENCE TO RELATED APPLICATIONS

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In embodiment vi R 1 is a substituted imidazothiazole group wherein the substituents are selected from methyl, ethyl, amino, fluorine, chlorine, amino and methylamino. Examples of alkoxy groups bearing a non-aromatic heterocyclic group as a substituent are those in which the heterocyclic group is a saturated cyclic amine such as morpholine, piperidine, pyrrolidine, piperazine, C 1-4-alkyl-piperazines, C 3-7-cycloalkyl-piperazines, tetrahydropyran or tetrahydrofliran and the alkoxy group is a C 1-4 alkoxy group, more typically a C 1-3 alkoxy group such as methoxy, ethoxy or n-propoxy.

The positional and thermal parameters of hydrogen atoms were constricted to ride on corresponding non-hydrogen atoms. Within the sub-set of alkynyl groups having 2 to 8 carbon atoms, particular examples are C 2-6 alkynyl groups, such as C 2-4 allynyl groups. The fused carbocyclic or heterocyclic ring can be optionally substituted by 0 to 4 groups R 10 as defined herein.

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As of some one ently rapping. Thus, unless indicated otherwise, the general preferences, definitions and examples set out for, e. The fused heterocyclic or carbocyclic group can be aromatic or non-aromatic but preferably is aromatic. The port was originally created by Andy Wooden, fau and VladKi, the project had no fixed home and its sources were distributed as tarballs, making it hard to maintain and provide updates. Gradually, the air sacs of the lungs become replaced by fibrotic tissue, which becomes thicker, causing an irreversible loss of the tissue's ability to transfer oxygen into the bloodstream.